…different HIV strains. Still, the findings offer hope for a cost-effective, long-lasting strategy to help reduce pediatric HIV and may eventually inform similar approaches for other infectious diseases, including malaria….

…a virus closely related to HIV and causes AIDS, when given before or after exposure. This study directly led to the development of Truvada, a drug that has reduced HIV…

…in people with HIV and may become powerful tools in future immunotherapies. Understanding HIV in the Brain Another major advancement came from California NPRC, where researchers discovered how HIV enters…

…Dr. Paiardini have made two significant advancements in the pursuit of a cure for HIV. Using nonhuman primates and the simian immunodeficiency virus (SIV), the best model for HIV infection…

…of long-term control of HIV and SIV without ART. This breakthrough brings us one step closer to a potential HIV cure, offering hope to millions affected by the disease worldwide….

…effective against other mutating viruses, including SARS-CoV-2. The vaccine platform, which uses cytomegalovirus (CMV) as a vector, was originally developed to fight HIV and tuberculosis. It works by inducing an…

…Led development of the WNPRC Scientific Protocol and Implementation Unit (SPI), driving research on HIV, COVID-19, Parkinson’s, and more. Mentored over 15 post-docs, 30 graduate students, and numerous undergraduates, fostering…

Researchers at Texas Biomedical Research Institute (Texas Biomed) have made significant progress in the fight against tuberculosis (TB) and HIV co-infection. The team, led by Professor Smriti Mehra, Ph.D., has…

…in patients on effective antiretroviral therapy (ART). Why This Matters While ART has transformed HIV from a terminal illness to a manageable condition, it doesn’t completely eradicate the virus. HIV…

…bigger picture: This research is part of a larger effort called ERASE HIV, which aims to develop innovative therapies to eliminate or control HIV without the need for lifelong medication….

The human immunodeficiency virus (HIV) remains a formidable challenge for medical researchers worldwide. While antiretroviral therapy (ART) has allowed individuals to manage HIV as a chronic condition and significantly improve…

…potential for widespread use of such therapies in HIV-infected patients. “This groundbreaking research not only offers hope for individuals living with HIV, but also represents a significant step forward in…

…for an Effective HIV Vaccine The challenge posed by HIV is two-fold: its rapid spread through the body within days of infection and its ability to reach peak viral levels…

…Infectious Disease 2. A Deadly Relationship: Stopping the Progression of Tuberculosis in HIV Patients Researchers at the Southwest National Primate Research Center have discovered chronic immune activation in the lungs…

While current HIV treatment reduces viral load, or the amount of HIV in the blood, there is no cure for the disease. Antiretroviral therapy (ART) involves either taking a shot…

HIV, human immunodeficiency virus, destroys CD4 cells, also known as helper T cells, in the immune system. Without these cells, bodies have a hard time fighting off various diseases. While…

…Metabolism, Palmer analyzed a body of evidence that looked at the metabolic changes that occur in cells when viral invaders, such as HIV, hepatitis B, or SARS-CoV-2, pose a threat….

…now live long lives with HIV, but researchers believe long-term viral control in the absence of ART (i.e. remission) might be possible. In pursuit of an HIV remission, researchers at…

…is the potential for stigma, similar to early days of HIV infection, that the virus is a disease of MSM. Like HIV, monkeypox can transmit between anybody who has close…

…HIV infections can progress to acquired immunodeficiency syndrome (AIDS), leading to a damaged immune system, severe opportunistic infections, and death. Most replicating HIV – and its monkey version, simian immunodeficiency…

…chimeric form of HIV. “Our study findings indicate leronlimab could be a new weapon against the HIV epidemic,” said Jonah Sacha, Ph.D., an Oregon Health & Science University professor at…

…children November 24, 2020: Learn about the monkeys behind COVID-19 vaccines and how the NPRCs accelerated the pace of discovery based on their HIV/AIDS expertise November 9, 2020: Southwest NPRC…

HIV (human immunodeficiency virus) attacks the body’s immune system, and if left untreated, HIV can lead to AIDS (acquired immunodeficiency syndrome). HIV/AIDS currently impacts 38 million people worldwide. While there…

…sequenced 5 percent of all cases, a figure that represents their decades of experience and their work at WiNPRC to stay ahead of global HIV, influenza and Zika virus pandemics….

In an effort to study more treatments for HIV, researchers at the Wisconsin National Primate Research Center are focusing on a gene that cured two men of HIV. Both men…

…for HIV is a real possibility. “This is an important development in what we hope will be an end to HIV/AIDS,” MacLean said. “The next step is to evaluate this…

…(SIV)-infected nonhuman primates treated with antiviral drugs. In humans, antiviral drugs can suppress human immunodeficiency virus (HIV) to the point of being undetectable in blood, but the virus embeds itself…

…and those in planning stages. The NPRCs remain dedicated to our other areas of study, including research into HIV/AIDS and other infectious diseases, the neurosciences, cardiovascular and respiratory health, genetics…

Tuberculosis (TB) and HIV are two of the world’s deadliest infectious diseases, and they’re far worse when they occur together. Now, Southwest National Primate Research Center (SNPRC) researchers at Texas…

Could a promising discovery about viral latency help scientists effectively combat human immunodeficiency virus (HIV)? The primary obstacle to a cure for HIV infection is the reservoir, or immune cells…

…called upon the National Primate Research Centers (NPRCs) – as NIH has for HIV/AIDS, Ebola, Zika and other infectious disease threats – to identify animal species for studying the SARS-CoV-2…

…infectious diseases that are associated with kidney failure, like human immunodeficiency virus (HIV) and coronavirus (COVID-19). NPRC scientists across the country are working to combat infectious diseases through a variety…

…months. The other half was untreated. Numerous factors—including HIV infection, diabetes, aging or other diseases—can cause latent bacteria to become symptomatic and infectious again. To test whether the antibiotics had…

…to learn if microbes living in the rectum and vagina—sites of HIV transmission—interacted with an experimental HIV vaccine similar to the HVTN 111 vaccine currently in early stage clinical trials…

…recent paper that considered information from four studies on macaques immunized against SIV (HIV’s relative) or the hybrid SHIV virus, the researchers concluded a certain type of immune system cell…

…of HIV (known as SHIV), when they received a combination of two antibodies 30 hours after being exposed to the virus. This is the first time a single dose of…

…weeks, the researchers gave the animals 10 weekly exposures to SHIV, the simian version of HIV. The results revealed animals in the two experimental groups experienced significant initial protection from…

Cells that harbor HIV, even while a person is on antiretroviral drugs, are referred to as the “reservoir”. Some of these cells might be able to self-renew/proliferate, thus continually replenishing…

…other institutions.” Understanding these mechanisms is just part of the equation in fighting HIV. See how other ongoing research at the NPRCs is helping purge HIV “reservoirs” from the body….

While no true cure for HIV/AIDS exists, patients can suppress the virus through a continuous regimen of medication. But now, scientists have discovered a new approach to dealing with HIV…

Rhesus macaques have long been considered the prime model for AIDS vaccine research because these monkeys’ immune systems are analogous to humans. In fact, most medications approved to treat HIV…

…outcome. For example, patients infected with HIV-1, a virus that causes AIDS, are more susceptible to tuberculosis infection. “A significant number of people entering Ebola Virus Treatment Units during the…

Tuberculosis is a major concern for HIV/AIDS patients, as a full one-third of all patients with the autoimmune disease die of complications from TB. But Professor Deepak Kaushal, PhD, of…

…flush out and kill HIV from reservoirs in the body where the virus lurks beyond the reach of antiviral therapy options. Current HIV treatment options can stop the disease from…

Young macaques form an important part of our work at the NPRCs, helping us discover new ways of treating deadly diseases like tuberculosis, HIV/AIDS, Zika and more. Two researchers at…

…treated this way were fully protected against the virus. “IgM can grab multiple particles like HIV-1 and SHIV very quickly and does not let go,” said Dr. Ruprecht. “Our study…

…New Orleans. “We are excited Dr. Kaushal will be joining the Texas Biomed and SNPRC team,” Dr. Schlesinger said. “He is a world-renowned researcher whose focus in tuberculosis and HIV,…

…by the HIV virus. But researchers at the University of Pittsburgh and the University of Wisconsin–Madison recently reported in Infection and Immunity that a new nonhuman primate model using Mauritian…

…NPRCs have led the way toward understanding and fighting HIV. The virus infects and kills millions globally; just last year, approx. 36.9 million people worldwide were living with HIV, and…

What doesn’t kill you might just save your life. At least, that’s the new thinking on how to combat SIV, a variant of HIV. This comes after researchers at the…

…one (Pfizer) at an NPRC (the Southwest NPRC). Several next generation vaccine candidates and therapeutics are currently being pre-clinically tested at different NPRCs. HIV/AIDS – The emergence of HIV/AIDS in…

Only one individual in history has been cured of HIV. This person is known as “the Berlin patient,” named for the location where the renowned HIV-ridding procedure took place. Scientists…